Panic (voiced by Matt Frewer) is the thin green-blue imp with long horns. His yellow eyes are set very close together, with a thin, black uni-brow, and his upper eyelids having a darker shade of purple. His nose is very small and a darker shade of pink than the rest of his skin. Pain's hair is maroon and styled into two horns, with his real, black horns sprouting out just behind, and his pointed tail is the same color as his hair. His wings, which have purple membranes, seem too small to actually fly with. His arms, though just as thin as Panic's, are spindly and end in four-fingered hands, as are his legs, which are much stockier and end in two-toed feet. Pain is much shorter and wider than his partner, with a large mouth filled with sharp teeth. He is the more assertive of the duo, and while more cunning, less likely to think things through properly, which is what gets him into painful situations. When he shape-shifts, it is usually into something short or fat (or both), and generally colored in red tones. True to his name, he is repeatedly injured through the film and animated series. Pain (voiced by Bobcat Goldthwait) is the fat purple-red imp with little horns and a bitten bat wing on the left side. Hades uses them as pawns in his schemes, including keeping an eye on Megara, shifting into bunnies, gophers, chipmunks, and birds to do so, and when he loses his temper, he occasionally uses them as punching bags.

Their shifting abilities do not seem to extend to voice-mimicking, and they have to do the best they can with their own voices.

Their shape-shifting abilities extend to being capable of shifting only part of their bodies, shifting into shapes both larger and smaller than they themselves are, and even more importantly, merging into a single form however, this seems to be a more temporary and harder-to-control ability. They appear to be immortal and capable of regeneration, but due to being demonic rather than godly, both imps are capable of feeling pain.

Neither Pain nor Panic are especially loyal to Hades, and serve him only because they fear him and possibly because he owns their souls.

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